Research Article

Volume 2 Issue 1 - 2020

E Coli & Electrolyte Depletion: The Cause of Parkinson’s; Schizophrenia. ALS; Alzheimer’s; & Cancer

*BScE, DULE, 23 Park Ave. Saint John, NB E2J 1R2, Canada*

***Corresponding Author:**Paul TE Cusack, BScE, DULE, 23 Park Ave. Saint John, NB E2J 1R2, Canada.

**Received:**October 27, 2020;

**Published:**November 20, 2020

Abstract

This paper synthesizes previous papers with the added twist of explaining the connection between bacteria and nervous system diseases. We make use of familiar AT Math solution as applied to contagions. We will see that E Coli and Cholera which cause watery diarrhea deplete the electrolytes in the body leading to detrimental affects on DNA Adenine. This paper is the key toward understanding the root cause of some major neurological diseases.

**Keywords:**AT Math; Golden Mean Parabola; Sugar Intake; E Coli; Cholera; Parkinson’s; Schizophrenia; ALS; Alzheimer’s; Cancer.Introduction

Continuing in the vein of what causes major neurological disorders, we have a paper that shows how electrolyte depletion through diarrhea caused by E Coli and Cholera may be the cause of various diseases. Once again AT Math plays a role in the mathematics underlying the phenomena. We begin with the familiar golden mean parabola and the logarithmic and exponential functions. We then move into the chemistry of excess sugar and the impact it has on bacterial growth, such a E coli. Next, we proved some calculations from the chemistry of E Coli which has been well studied. Finally, we consider pH and how acid environments contribute to bacteria growth. We begin with the familiar ln function.

**Golden Mean Parabola**

Ln t=e

^{-t}

Derivative:

1/t= (-e

^{-t-1})/ (-1)

1/t=e

^{-t-1}

Integrate both sides:

Ln (1/t) =Ln e

^{(-1-t)}

Ln (1/t) =-1-t

Aside:

Ln t=e

^{-t}

Derivative:

1/t=-e

^{-t}/-1=e

^{-t}

t=1/e

^{-t}

t=e

^{t}

1/e

^{t}=e

^{exp(-1-t)}

Ln (e

^{-t})= e

^{(-1-t)}

Ln (-t) =Ln e

^{(-1-t)}

Ln -t=-1-t

t=-1

∫dt/dt=∫1+? =t+?

t+?=1

t=?-1

Let ?=0

t=-1

-t=e

^{exp(1-t)}

Take ln of both sides twice:

-Ln Ln t=(-1+t)

Ln Ln t-t=-1

1/Ln t+1=t

Integrate both sides:

∫1/Ln t=∫t-1

Ln t=t²-t

From above:

e

^{-t}=t²+t

Take Ln of both sides:

-t=Ln t²+Ln t

Take derivative:

?=1/t²+1/t

?=(1+t)/t²

Let ?=1

Golden Mean Parabola

t²-t-1=0

t=1.618; -0.618

Since one cycle is 2π; then:

2π/3=212

M=Ln t

=Ln 212

=1.550

TE=M [0.15915]

= (0.1550)(0.15915)

=246.68

E=1/t=405.38

E=Mc²

405.4=Mc²

M=451

M=Ln t

t=166.99~1.57=π/2

PE=KE=t

Mc²=1/2Mv²

1/2=c/v

1/2=9/v

v=18

t=KE=1/2Mv²

=1/2(Ln π/2) (18)²

=73.156

E=1/t=0.01367

E²+E-2=t

(0.01367)²+0.01367-2

=-1.986~-2

t²-t-1=E

t²-t-1=--1.986

t²-t+1=0

t=1.314; 3.1429=Pi

2π/3=212

M=Ln t

=Ln 212

=1.550

TE=M [0.15915]

= (0.1550)(0.15915)

=246.68

E=1/t=405.38

E=Mc²

405.4=Mc²

M=451

M=Ln t

t=166.99~1.57=π/2

PE=KE=t

Mc²=1/2Mv²

1/2=c/v

1/2=9/v

v=18

t=KE=1/2Mv²

=1/2(Ln π/2) (18)²

=73.156

E=1/t=0.01367

E²+E-2=t

(0.01367)²+0.01367-2

=-1.986~-2

t²-t-1=E

t²-t-1=--1.986

t²-t+1=0

t=1.314; 3.1429=Pi

Proton Motive Force

C

C

_{8H11NO2 + C7H16NO2+ C13H16 N2O2 + C8H ON4O3 + C5H5N5 Fe3+ +NaCl +H2O2 → Dopa. + Ach. + Melatonin + Caffeine and Adenine+ Iron and Chlorine + Hydrogen Peroxide → C41H48N13O12 + 3 Fe+2+2NaCl+5O2 ==> 41CH + 12NO-+Fe2O3 +2NaOH + FeCl2-+ H2NOH +2H2O2-2 }Methylene (Carbene) Hydroxylamine

a CH+ C

Carbene +Cortisol (Stress) Sugar Hydroxylamine

The excess sugar makes the bodily system acidic. Bacteria need iron Fe +3 to grow.

amu= (14.016+362.46+30.006+396.33=1072.866

1072.866 x 6.026=6461.87 g

6461.87g x/ 0.994 g/mole of blood=65.008 moles

Normal pH=7.35-7.45 Say 7.4

pH=Ln [H+]

e

[H+]=moles of H+/moles of solute

6.1125=Mol 0f H+/6500

Mol of H+=3973

H+ =1.008 g/mol x 4 moles=4.00 =|D|

4.00 x 6.023=24120.8

e

Moles of Sugar:

C22H44O22=660.33 g/mol x 6.023=397.716 g~4g of Sugar

=Moles of H+

H+1.008 g/mol x 397.716=4.008977~4.00g of H+

a CH+ C

_{22}H_{30}O_{5}+ 10 NO^{-}+ 22 H_{2}O**→**C_{22}H_{44}O_{22}+10 H_{2}NOH + 2O_{2}+OH^{-}Carbene +Cortisol (Stress) Sugar Hydroxylamine

The excess sugar makes the bodily system acidic. Bacteria need iron Fe +3 to grow.

amu= (14.016+362.46+30.006+396.33=1072.866

1072.866 x 6.026=6461.87 g

6461.87g x/ 0.994 g/mole of blood=65.008 moles

Normal pH=7.35-7.45 Say 7.4

pH=Ln [H+]

e

^{-7.4}=6.1125[H+]=moles of H+/moles of solute

6.1125=Mol 0f H+/6500

Mol of H+=3973

H+ =1.008 g/mol x 4 moles=4.00 =|D|

4.00 x 6.023=24120.8

e

^{0.241208}=127.3=4/π=ρMoles of Sugar:

C22H44O22=660.33 g/mol x 6.023=397.716 g~4g of Sugar

=Moles of H+

H+1.008 g/mol x 397.716=4.008977~4.00g of H+

So we consider that E Coli is the proximate cause of various disorders including Parkinson’s; Schizophrenia; ALS; Alzheimer’s disease; and Cancer.

We examine E Coli in more detail.

E Coli double in growth every 20 minutes (1/3 hour)

Since it follows exponential growth, we have:

2=a

2=a

a

A full cycle is 2π rads

2π/7=0.8976=c²

GMP: t=1/3

(1/3)²-(1/3)-1=1.22222

E Coli has 20% of its protein in its envelope

M=Ln t

=Ln (1/3)

=1.096

(20%/100%) M=21972/χ

χ=1.0986

M

TE=M[0.15915]

=1.0986[0.15915]

=174.842~1 rad

t=E²-E-2

t=30.743

E=1/t=3.2527

100% M=1.0986/30 genes=0.03663 gm/gene

3.2527/0.03662=0.88823

GMP: = E=1.099~11 base pairs

4 mol of sugar=amu x mol x Avg.

=660.33 x 4 x 6.023=1590.86~1591

We examine E Coli in more detail.

E Coli double in growth every 20 minutes (1/3 hour)

Since it follows exponential growth, we have:

2=a

_{0}e^{t}2=a

_{0}e^{(1/3)}a

_{0}=1.4335=1/698=1/7 Economic Multiplier.A full cycle is 2π rads

2π/7=0.8976=c²

GMP: t=1/3

(1/3)²-(1/3)-1=1.22222

E Coli has 20% of its protein in its envelope

M=Ln t

=Ln (1/3)

=1.096

(20%/100%) M=21972/χ

χ=1.0986

M

_{T}=21972TE=M[0.15915]

=1.0986[0.15915]

=174.842~1 rad

t=E²-E-2

t=30.743

E=1/t=3.2527

100% M=1.0986/30 genes=0.03663 gm/gene

3.2527/0.03662=0.88823

GMP: = E=1.099~11 base pairs

4 mol of sugar=amu x mol x Avg.

=660.33 x 4 x 6.023=1590.86~1591

E Coli and Cholera cause watery diarrhea which depletes the body of electrolytes. Electrolytes such as Salt and Potassium are essential for the functioning of the nervous system as they are the ions that cause a nerve to surge with a signal.

So how does electrolyte depletion cause the genetic mutation that leads to a genetic disposition of r these nervous system diseases? The answer lies in a “special membrane protein that binds to an 11 base-pair sequence (5’-AAGTGCGGTCA-3’) that occurs frequently in Haemophilus DNA....” [17]

Let us consider the A o=Adenine molecule: C5H5N5

The chemical mol balance equation is:

C

(Adenine+ Sugar +Salt + Hydrogen Peroxide + Proton ==>

27CH+22HCl+22NaOH +5NO+ (1/2) O

Carbene + Hydrochloric Acid + Sodium Hydroxide+ Nitrate +Oxygen

The chemical mol balance equation is:

C

_{5}H_{5}N_{5}+C_{22}H_{44}O_{22}+22NaCl +3H_{2}O_{2}+ 8H_{2}==>(Adenine+ Sugar +Salt + Hydrogen Peroxide + Proton ==>

27CH+22HCl+22NaOH +5NO+ (1/2) O

_{2}Carbene + Hydrochloric Acid + Sodium Hydroxide+ Nitrate +Oxygen

Pathways of fermentation of sugars by various microorganisms need protons(Hydrogen atoms). Pyruvic acid C3H4O3 produces Formic acid; Acetyl CoA; Acetic Acid; Ethanol; Acetoacetic acid; Butyric acid; Butanol; Acetone Isopropanol; Butanediol; Propionic acid; Lactic acid; Acetaldehyde; Ethanol requires 16 Hydrogen atoms which is what we have above.[17]

Now, excess sugar causes the body to become acidic. Thus, pH varies from the normal pH=7.4

pH = Moles of [H

pH =7.4

Ln 7.4=2

2 = (8x2)/Moles of Solute

Moles of solute=8

8 x 6.023 =481.8

GMP: E=-1.249~-1.25=E

pH = Moles of [H

^{+}] /Mol of solute.pH =7.4

Ln 7.4=2

2 = (8x2)/Moles of Solute

Moles of solute=8

8 x 6.023 =481.8

GMP: E=-1.249~-1.25=E

_{min}Conclusion

So, we see that these diseases of the nervous system follow AT MATH. E Coli causes depletion of the electrolytes that are necessary for normal A- adenine in the DNA molecules.

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**Paul TE Cusack. (2020). E Coli & Electrolyte Depletion: The Cause of Parkinson’s; Schizophrenia. ALS; Alzheimer’s; & Cancer.**

*Citation:**Journal of Brain and Neurological Disorders*2(1).

**Copyright:**© 2020 Paul TE Cusack. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.